Puffle-Pod Marine Evacuation System (POMES)

The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.Evacuation systems have always played a crucial part when designing a transport system. The cornerstone of these systems is to get people to safety in the quickest and safest way possible. When it comes to marine systems, the requirements greatly differ in comparison to those on land and in air. On a day with highly inclement and fierce weather, in the middle of the ocean, getting the crew to safety through a chute or a slide would expose the crew to ferocious danger. Thence, the proposed Puffle-Pod Evacuation System introduces a more protected and secure evacuation without putting the lives of the crew at high risk

Rapid prediction of NMR spectral properties with quantified uncertainty

open access articleAccurate calculation of specific spectral properties for NMR is an important step for molecular structure elucidation. Here we report the development of a novel machine learning technique for accurately predicting chemical shifts of both 1H and 13C nuclei which exceeds DFT-accessible accuracy for 13C and 1H for a subset of nuclei, while being orders of magnitude more performant. Our method produces estimates of uncertainty, allowing for robust and confident predictions, and suggests future avenues for improved performance

Stereo-Aware Extension of HOSE Codes

The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.Descriptions of molecular environments have many applications in chemoinformatics, including chemical shift prediction. Hierarchically ordered spherical environment (HOSE) codes are the most popular such descriptions. We developed a method to extend these with stereochemistry information. It enables distinguishing atoms which would be considered identical in traditional HOSE codes. The use of our method is demonstrated by chemical shift predictions for molecules in the nmrshiftdb2 database. We give a full specification and an implementation

Externalities in a Life-Cycle Model with Endogenous Survival

We study socially vs. individually optimal lifecycle allocations of consumption and health care, when individual health expenditure curbs own mortality but also has a spillover effect on other persons' survival. Such spillovers arise, for instance, when health care activity at aggregate level triggers improvements in treatment through learningbydoing (positive externality) or a deterioration in the quality of care through congestion (negative externality). We combine an agestructured optimal control model at population level with a conventional lifecycle model to derive the social and private value of life. We then examine how individual incentives deviate from social incentives and how they can be aligned by way of a transfer scheme. The agepatterns of socially and individually optimal health expenditure and the transfer rate are derived. Numerical analysis illustrates the workings of our model.Demand for health, externality, life-cycle-model, optimal control, tax-subsidy, value of life.

The reproductive value as part of the shadow price of population

The reproductive value (see Fisher [10]) arises as part of the shadow price of the population in a large class of age-structured optimal control models.life history, reproductive value

The Reproductive Value as Part of the Shadow Price of Population

The reproductive value (see Fisher 1930) arises as part of the shadow price of the population in a large class of age-structured optimal control models.Reproductive value, distributed optimal control theory, McKendrick equation, shadow price, indirect effect.

The Reproductive Value in Distributed Optimal Control Models

We show that in a large class of distributed optimal control models (DOCM), where population is described by a McKendrick type equation with an endogenous number of newborns, the reproductive value of Fisher shows up as part of the shadow price of the population. Depending on the objective function, the reproductive value may be negative. Moreover, we show results of the reproductive value for changing vital rates. To motivate and demonstrate the general framework, we provide examples in health economics, epidemiology, and population biology.Reproductive value, distributed optimal control theory, McKendrick, shadow price, indirect effect, health economics, epidemiology, population biology.